Mollarets meningitis caused by herpes simplex virus type. The authors accept the interpretation as macrophages of the endothelial cells. Mollaret meningitis is characterized by three or more episodes of benign recurrent aseptic meningitis in which symptoms and signs resolve spontaneously. Because of its rarity, it is difficult to estimate the exact number of individuals affected by this condition. When initially described by mollaret, this form of aseptic meningitis had no identifiable infecting agent. Mollaret syndrome definition of mollaret syndrome by. Benign recurrent aseptic meningitis mollarets meningitis. Mollaret s meningitis is caused by herpes simplex virus. Mollaret meningitis, recurrent aseptic meningitis, fever. Synonyms for mollaret meningitis in free thesaurus. Mollarets meningitis the lancet infectious diseases.
Mollaret meningitis synonyms, mollaret meningitis antonyms. Recurrent aseptic meningitis secondary to intracranial epidermoids. Recurrent lymphocytic meningitis positive for herpes simplex. Common signs and symptoms during an episode may include severe headache, fever, nausea, vomiting, sensitivity to light photophobia, and stiff neck.
In this article a case of mollaret meningitis related to type 1 hsv is described. Mollaret meningitis was first described by mollaret in 1944 as a form of aseptic meningitis. Mollaret meningitis journal of the neurological sciences. They were identical to those in an entity known as mollarets.
The peripheral white blood cell count alone is not help. From 1994 to 2006 she had suffered six more episodes of meningitis every 23 years. The interest is the demonstration of the herpes simplex virus type 1 within the. Mollaret meningitis genetic and rare diseases information. The clinical features in a patient with recurrent brief episodes of aseptic meningitis are described. Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Mollarets meningitis has been characterized by unique abnormalities found on serial csf examinations. Pdf on oct 1, 2004, christian wejse and others published picture of the.
There are a number of risk factors for fungal meningitis, including the use of immunosuppressants such as after organ transplantation, hivaids, and the loss of immunity associated with aging. Diagnosis, initial management, and prevention of meningitis. Get a printable copy pdf file of the complete article 869k, or click on a page image below. Mollarets meningitis benign recurrent aseptic meningitis. However, in contrast to bacterial meningitis, many patients with aseptic meningitis particularly those who have disease caused by viruses or. Bacteria called neisseria meningitidis cause meningococcal disease.
The disease is characterised by recurrent at least three episodes, benign no longterm sequelae and brief 25 day episodes of aseptic lymphocytic meningitis, alternating with symptomfree interval, mostly caused by hsv2 infection. Abstractmollarets meningitis is a rare disease characterized by recurrent and selflimited. Mollarets meningitis and herpes simplex virus type 1 nejm. Herpes simplex type 2 virus is the causative agent in virtually all cases. Find mollarets meningitis information, treatments for mollarets meningitis and mollarets meningitis symptoms. Mollaret meningitis article about mollaret meningitis by. We report a case of mollaret meningitis in a sevenyearold girl who presented with four aseptic meningitis episodes in one year.
With this type of meningitis, there is usually rapid onset of symptoms and resolution without residual damage to the nervous system. All three patients had shortlived attacks of fever, headache and vomiting, meningeal irritation, and generalized myalgia. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. In recent years there has been increasing evidence to implicate the herpes simplex virus 2 hsv2 in many cases. It has been suggested that if the strict criteria above are followed, these cases should be excluded, and the term mollaret s meningitis reserved for true idiopathic cases. Mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. The 35yearold praised simon read and matthew laws from the east of england ambulance service nhs trust eeast for their care after her condition rapidly deteriorated. Mollaret s meningitis is a chronic recurrent form of herpes meningitis. It is characterized by repeated episodes of meningitis, typically lasting two to five days, occurring weeks to years apart.
In the original description of three patients with recurrent episodes of meningitis over a 15year period, the csf was notable for a leukocytosis and an unusual cell type originally thought to be of endothelial origin. You get it when a virus enters the body through the nose or mouth and travels to the brain. However, recent research and studies have suggested that it may be more common than initially thought. Mollaret meningitis definition of mollaret meningitis by. Cerebrospinal fluid csf examination remains the sole diagnostic modality. Herpes simplex virus type 2associated recurrent aseptic. Mollarets meningitis an overview sciencedirect topics. Sometimes funguses, cancers, head injuries or other factors can cause meningitis, but cases from these sources are rare. Mollaret s meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Symptoms of mollaret meningitis, which last from 1 to 7 days, include headache, neck ache, fever, and neck stiffness.
Get a printable copy pdf file of the complete article 869k, or click on a page image below to browse page by page. The disease is most often caused by herpes simplex virus type 2 hsv2 and less frequently by other viruses, autoimmune disorders, or medication. Recurrent aseptic meningitis secondary to intracranial epidermoid cyst and mollarets meningitis. Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges.
Presented here is a new case of benign recurrent aseptic meningitis, or mollarets meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain. Mollarets meningitis caused by herpes simplex virus type 2. Amanda has been living with mollarets meningitis a rare recurring viral form of the disease for more than six years. Descrita por primera vez en 1944 por pierre mollaret como una meningitis endoteliolinfocitica recurrente caracterizada por presentarse en pacientes por lo demas sanos. Sep 02, 2016 mollaret meningitis is thought to be rare. Ideal sources for wikipedias health content are defined in the guideline wikipedia. Mollaret s meningitis has been characterized by unique abnormalities found on serial csf examinations. Mollarets meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. Pdf on oct 1, 2014, zaw min and others published mollarets meningitis find, read and cite. Mollaret syndrome recurrent benign viral infection. About 1 in 10 people have these bacteria in the back of their nose and throat without being ill. Mollaret s meningitis and differential diagnosis of recurrent meningitis. An epidermoid cyst of the 3rd ventricle was verified by necropsy in a man of 60 with three episodes of mollarets aseptic leukocyticendothelial meningitis. The trip database provides clinical publications about.
The features of these activated monocytes were compatible with those of mollarets cells, and csf herpes simplex virus type 2 hsv2 pcr assay. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. Recurrent lymphocytic meningitis rlm is a rare disease, characterized by attacks of sudden onset aseptic meningitis followed by complete recovery and unpredictable recurrences. Mollarets meningitisrecurrent aseptic meningitishsv2 virus. Mollaret s meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever. This is a rare condition believed to be caused in many cases by infection with a member of the herpes family of viruses. A search of the existing medical literature revealed 58 previously reported cases of mollarets meningitis in which samples of cerebrospinal fluid were tested for herpes simplex. Mollaret meningitis the turkish journal of pediatrics. A rare form of aseptic meningitis characterized by a recurrent pattern with symptomfree intervals between episodes. Herpes simplex virus type 2associated recurrent aseptic mollarets meningitis in genitourinary medicine clinic.
If you have experienced viral meningitis more than once, we would encourage you to ask your gp to investigate it to try and determine the cause. Mollarets meningitis is the name given to a recurring form of meningitis. It is not known why one person gets meningitis when others exposed to the same germs do not get as sick, or dont get sick at all. Herpes simplex type 2 in a patient with mollarets meningitis. Presented here is a new case of benign recurrent aseptic meningitis, or mollaret s meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain. Looking for online definition of mollaret meningitis in the medical dictionary. Contribution to the background of mollarets meningitis.
We present a case of a 27yearold woman with mollarets meningitis related to viral infection with herpes simplex virus type 2 confirmed by cerebrospinal fluid. Herpes simplex virus type 2associated recurrent aseptic mollaret s meningitis in genitourinary medicine clinic. Mollaret s meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for mollaret. Mollarets meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever.
Recurrent lymphocytic meningitis positive for herpes. Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and meningeal irritation with no obvious etiology. Jan 25, 2019 mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Pdf mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Mollarets meningitis fulltext european neurology 2008, vol.
Mollarets meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. Recurrent aseptic meningitis secondary to intracranial. Pcr was most sensitive in detecting hsv2 dna from cerebrospinal fluid if the sample was taken 25 days after symptom onset. Pdf on oct 1, 2004, christian wejse and others published picture of the month. Mollarets meningitis is a chronic recurrent form of herpes meningitis. Aseptic meningitis often has a similar presentation to that of bacterial meningitis ie, fever, headache, altered mental status, stiff neck, photophobia, which can be a lifethreatening illness. Pdf mollaret s meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Canadian journal of neurological sciences journal canadien des sciences neurologiques, vol. Hsv2, less often hsv1 meningitis is clinically indistinguishable from cases of idiopathic mollarets meningitis 10, 11. Eighteen csf samples from 14 patients were studied along with the clinical data. You get it when a virus enters the body through the nose or mouth and travels. Since mollaret s meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. Jun 25, 2004 presented here is a new case of benign recurrent aseptic meningitis, or mollarets meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain reaction test.
In general, meningitis caused by a virus is less serious than meningitis caused by bacteria. Recurrent benign lymphocytic meningitis clinical infectious. Fulltext pdf recurrent aseptic meningitis with reversible cerebral vasoconstriction. Hendler n, schlaeffer f, zirkin h, rabinowitz b, berginer vm. They bring forward evidence for the blastomatous nature of partly cornified epithelial cells present in their case. Get a printable copy pdf file of the complete article 869k. Since mollarets meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred. Mollaret meningitis genetic and rare diseases information center. Recurrent herpes simplex type 2 virus mollaret meningitis jabfm. This syndrome is associated with transient neurological symptoms in onehalf of afflicted patients.
Mollarets meningitis is caused by herpes simplex virus. Recurrent meningitis rm is a rare condition classically known as mollarets syndrome2 defined by two or more episodes of. Cases of idiopathic recurrent benign aseptic meningitis were first described by. Mollarets meningitis and differential diagnosis of recurrent. Tell a friend about us, add a link to this page, or visit the webmasters page for free fun content. Mollarets meningitis and differential diagnosis of recurrent meningitis. Mollaret meningitis find, read and cite all the research you need on. Get a printable copy pdf file of the complete article 869k, or click on a page image. Presented here is a new case of benign recurrent aseptic meningitis, or mollarets meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain reaction test. We found the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 hsv2 was 2. Lol the disease is felt to be benign as much for the patient as it is to their contacts.
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